Researchers at Sungkyunkwan University in South Korea have developed a device that looks like an ordinary glue gun but performs something extraordinary—it prints bone grafts directly onto fractures during surgery. This innovation could transform orthopedic treatments in the near future.
How the Device Works
The tool extrudes a biocompatible mixture of polycaprolactone (PCL) and hydroxyapatite (HA), both of which support bone growth. Because the material melts at just 60 °C, surgeons can safely apply it without damaging surrounding tissue. Instead of relying on pre-designed implants, doctors now create customized grafts on the spot, ensuring a perfect fit for each fracture.
Built-In Infection Protection
To reduce the risk of infection, the researchers embedded antibiotics such as vancomycin and gentamicin into the graft material. These drugs release slowly over several weeks, protecting the wound site while minimizing systemic side effects. By delivering antibiotics directly where they are needed, the technique also lowers the chance of antibiotic resistance.
Promising Preclinical Results
In trials with rabbits, the surgical team applied the 3D-printed grafts directly to femoral fractures. Within 12 weeks, the animals showed stronger bone regeneration than those treated with traditional bone cement. The grafts improved bone thickness, density, and strength, while the printed scaffolds gradually degraded as natural bone filled in. Importantly, the team observed no infections or tissue damage.
Looking Ahead
Although researchers still need to validate the device in larger animals and secure regulatory approvals, they believe this handheld “glue gun” could soon make fracture surgeries faster, safer, and more cost-effective. By uniting 3D printing, biodegradable materials, and antibiotic delivery, the tool represents a bold step toward personalized bone repair.
